Risk Management

Study A Phase 3

Risk Mitigation Risk Level Logged Date
Site 101 temporarily closed due to COVID-19 Resourced patient follow up capacity with Leapcure Medium 2024-03-23
Belgium EC approval delay Reallocate media Low 2024-09-10
Screened patients (3) no longer comfortable due to COVID-19 risk Resourced patient recruitment to targeted sites with Leapcure High 2024-06-09

Study B Phase 2

Risk Mitigation Risk Level Logged Date
COVID-19 caused four month delay average to SIV schedule Increased resourcing of patient pre-registry Medium 2024-05-25
Site 101 temporarily closed due to COVID-19 Resourced patient follow up capacity with Leapcure Medium 2024-03-14
Delayed LIRB approval from UCSF None Low 2024-07-19

Study C Phase 2

Risk Mitigation Risk Level Logged Date
Site selection delayed due to travel restrictions Increased site selection options and capabilities Medium 2024-04-30
Possible manufacturing delays Resourcing alternative source Medium 2024-05-22